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KMID : 0369820140440010009
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Jorunal of Korean Pharmaceutical Sciences
2014 Volume.44 No. 1 p.9 ~ p.14
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Surface characterization of 2-hydroxypyrimidine sulphate by inverse gas chromatography
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Praveen Kumar B.
Madhusudana Reddy T.
Reddy K. S.
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Abstract
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The net retention volumes, VN, of n-alkanes and polar probes on 2-hydroxypyrimidine sulphate (2-HPS) drug surface are determined at 323.15, 328.15 and 333.15 K using inverse gas chromatography. The dispersive surface free energy, γdSγSd of 2-HPS are evaluated by applying Schultz method as well as Dorris?Gray method and found that γdSγSd values are higher by 8 per cent in the latter method. The γdSγSd values are decreasing in both the methods with increase of temperature. The specific component of the free energy of adsorption, ΔGSaΔGaS , for polar probes are obtained by three methods proposed by Schultz et al., Saint Flour?Papirer and Sawyer?Brookman. The Lewis acid?base parameters, Ka and Kb, are calculated using ΔGSaΔGaS values. The surface character value, S = (Kb/Ka) according to the Schultz et al., is found to be 3.9 whereas the S value in the other two methods are found to be 6.2 and 5.6. The results demonstrate that the 2-HPS powder surface contain relatively more basic sites and can interact strongly in the acidic media.
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KEYWORD
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Inverse gas chromatography (IGC), 2-Hydroxypyrimidine sulphate (2-HPS), Dispersive surface free energy, Lewis acid?base parameters
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